I am editing a special issue in the #openaccess journal Brain Sciences about “Modulatory Effects of Deep Brain Stimulation on Distributed Brain Networks“. In case you are working on topics that combine brain stimulation with connectomics, would like to write a review or short report in that domain, please consider submitting to this issue – deadline is […]
Three months into 2018, there have been several studies that used Lead-DBS to answer very interesting questions briefly summarized below. 1. Siobhan Ewert and Todd Herrington could recently show that automated segmentations of the STN and GPi performed with Lead-DBS are nearly as precise as manual expert segmentations of the same structures in both a high-definition MRI […]
We just published a new study spearheaded by R. Ryan Darby that used the Lesion Network Mapping approach developed by Michael Fox to analyse lesion induced criminal behavior. The study has been featured on multiple news outlets such as WSFA, Der Spiegel, The Independent and El País. Findings show that lesions leading to criminal behavior are connected […]
In a new BPS study (Prospective Validation That Subgenual Connectivity Predicts …) spearheaded by Anne Weigand and led by Michael D Fox, we were able to explain TMS treatment response by functional connectivity between the stimulation site in the left dorsolateral prefrontal cortex and the subgenual cingulate cortex. Specifically, strength of anticorrelations between DLPFC and subgenual were predictive […]
Inside a new version of Lead-DBS (v2.0.0.6) released yesterday, we included the pallidal theta activity sweet spot defined in A localized pallidal physiomarker in cervical dystonia as well as optimal stimulation targets defined in Thomas Schönecker‘s Article Postoperative MRI localisation of electrodes and clinical ef… and Philip Starr’s Article Microelectrode-guided implantation of deep brain stimulators…. Since all three spots fall into a very […]
In a new study (A localized pallidal physiomarker in cervical dystonia) led by Wolf-Julian Neumann with Siobhan Ewert, Julius Huebl, Christof Brücke, Gerd-Helge Schneider and Andrea A Kühn, we were able to relate pallidal theta power to dystonic symptom severity for the first time. Furthermore, using the “Subcortical Electrophysiology Mapping (SEM)” approach developed as part of Lead-DBS (implemented inside the “Lead Group” module), […]
Till Dembek created a segmented Lead Mesh that allows us to run our FEM-calculations (see Connectivity Predicts deep brain stimulation outcome in Park…; model implemented based on SimBio with great help from Johannes Vorwerk) to create VTAs for these electrodes.
We are proud to release Lead-DBS 2.0 to the community – an open source tool to localize Deep Brain Stimulation (DBS) electrodes in the human brain. A detailed description of all major new features is available here [http://www.lead-dbs.org/?p=3174], but in a nutshell they are: DISTAL atlas: A detailed brain atlas of the human subcortex based on histology […]
Summary of novel subcortical atlas that is “made for Lead-DBS”, based on multispectral high-resolution MNI template, histology and structural connectivity (Ewert et al., 2017) here: http://www.lead-dbs.org/?page_id=2911 Dataset out soon, original publication here:http://www.sciencedirect.com/science/journal/aip/10538119?sdc=1
